BACKGROUND Topical application of glyceryl trinitrate (GTN) ointment heals chronic anal fissures, providing an alternative to the traditional first line treatment of surgical sphincterotomy. AIMS To determine the most effective dose of topical GTN for treatment of chronic anal fissures and to assess long term results. METHODS Seventy consecutive patients with chronic anal fissure
Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
An anal fissure is a tear in the skin lining the anal canal. Topical application of glyceryl trinitrate to the anal canal reduces the anal pressure and increases the blood flow, thereby reducing pain.